China (Mainland)
DHPG Cytovene Cymevene ganciclovir factory in China high quality CAS NO.82410-32-0
- FOB Price: USD: 280.00-296.00 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: L/C,T/T
- Available Specifications:
1(50-100)Kilogram1(1-2)Kilogram
- Product Details
Keywords
- API
- intermediate
- gancyclovir
Quick Details
- ProName: DHPG Cytovene Cymevene ganciclovir fac...
- CasNo: 82410-32-0
- Molecular Formula: C9H13N5O4
- Appearance: White or almost white crystalline powd...
- Application: 82410-32-0
- ProductionCapacity: Metric Ton/Day
- Purity: 99
- LimitNum: 1 Kilogram
Superiority
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Details
Ganciclovir is a synthetic analogue of 2′-deoxy-guanosine. It is first phosphorylated to ganciclovir monophosphate by a viral kinase encoded by the cytomegalovirus (CMV) gene UL97 during infection. Subsequently, cellular kinases catalyze the formation of ganciclovir diphosphate and ganciclovir triphosphate, which is present in 10-fold greater concentrations in CMV or herpes simplex virus (HSV)-infected cells than uninfected cells.
Ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate (dGTP) incorporation into DNA and preferentially inhibits viral DNA polymerases more than cellular DNA polymerases. In addition, ganciclovir triphosphate serves as a poor substrate for chain elongation, thereby disrupting viral DNA synthesis by a second route.